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KMID : 0811720050090000055
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Korean Journal of Physiology & Pharmacology
2005 Volume.9 No. 0 p.55 ~ p.0
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Effects of 5-HT1 Receptor Agonist on the Excitability of Medial Vestibular Nuclear Neurons
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Jang Myung-Joo
Jang Su-Jeong
Park Jin
Jeong Han-Seong
Huang Mei
Park Jong-Seong
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Abstract
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The aim of this study is to explore the action of 5-HT1 receptor on spontaneous firing activity of the rat medial vestibular nuclear neurons by patch clamp experiments. The spontaneous firing was increased in 45.5% and decreased in 54.5% of the neurons tested with 5-carboxamidotryptamine, non-selective 5-HT1 receptor agonist. And the whole potassium currents of medial vestibular nuclear neurons was decreased in 64% and increased in 36% of cells tested with 5-carboxamidotryptamine. The spontaneous firing rate was increased by 8-OH-DPAT, selective 5-HT1A receptor agonist in 73.3% and was not changed in 26.7%. Whole potassium currents were decreased in 84.2% and was not affected in 15.8% by 8-OH-DPAT. These results suggest that 5-HT1A receptor of the medial vestibular nuclear neurons mediates excitatory effects whereas inhibitory effects are mediated by other 5-HT1 receptors.
Source: Korean Journal of Physiology & Pharmacology.2005 Oct;9(Suppl I):S82-S82
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KEYWORD
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5-hydroxytryptamine, Medial vestibular nucleus, Potassium current
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